MIRA INFORM REPORT

 

 

Report Date :

12.04.2007

 

IDENTIFICATION DETAILS

 

Name :

SIRO CLINPHARM PRIVATE LIMITED.

 

 

Registered Office :

63 Lady Ratan Tata Medical And Research Centre 31, Maharshi Karve Marg, Mumbai 400021   Maharashtra.

 

 

Country :

India

 

 

Financials (as on) :

31.03.2006

 

 

Date of Incorporation :

21.03.2000

 

 

Com. Reg. No.:

11-125061

 

 

CIN No.:

[Company Identification No.]

U24230MH2000PTC125061

 

 

Legal Form :

Private Limited Liability Company

 

 

Line of Business :

Subject is a  pharmaceutical commercialisation service provider offering solutions in clinical staffing, biostatistics and data management

 

 

RATING & COMMENTS

 

MIRA’s Rating :

Ba

 

RATING

STATUS

PROPOSED CREDIT LINE

41-55

Ba

Overall operation is considered normal. Capable to meet normal commitments.

Satisfactory

 

Maximum Credit Limit :

USD 640000

 

 

Status :

Satisfactory

 

 

Payment Behaviour :

Regular

 

 

Litigation :

Clear

 

 

Comments :

Subject is a Well –established and reputed company having satisfactory track , Directors are reported as experienced and respectable businessman . Trade relations are reported as fair. Business is active. Payments are usually correct and as per commitments.

 

The company can be considered normal for business dealings at usual trade terms and conditions.

 

 

LOCATIONS

 

Registered Office :

63 Lady Ratan Tata Medical And Research Centre 31, Maharshi Karve Marg Mumbai 400021, Maharashtra , India

Tel No.:

91-22-22844011

E-Mail :

info@siroindia.com

 

 

Corporate Office :

Dil Premises, Swami Vivikanand Road, Near Tatvagyan Veedyapeeth , Ghodbunder Road , Thane (W) 400607 , India.

Tel. No.:

91-22-25848000

Fax No.:

91-22-25848475-79

E-Mail :

bd@siroindia.com

hr@siroindia.com

 

 

DIRECTORS

 

Name :

Mr. Gautam V. Daftary

Designation :

Director

Date of Birth/Age :

03.10.1959

Date of Appointment :

21.03.2000

 

 

Name :

Mr. Bharat V  Daftary

Designation :

Director

Date of Birth/Age :

01.12.1956

Date of Appointment :

21.03.2000

 

 

Name :

Mr. Dilip J Mehta

Designation :

Director

Address :

870 United Nations Plaza New York. US  NY10017

Date of Birth/Age :

07.04.1932

Passport No.:

155462546

Pan No.:

00505483

Date of Appointment :

18.04.2002

 

 

Name :

Mr. Raju R Shah

Designation :

Director

Date of Birth/Age :

09.01.1960

Date of Appointment :

18.04.2002

 

 

Name :

Mr. Madusudan Shankar  Vaidya

Designation :

Additional Director

Address :

13 , Vaibhav , 220/222 Cadell Road , Mahim Mumbai 400016 Maharashtra

Date of Birth/Age :

13.04.1935

Date of Appointment :

20.08.2006

Income - tax Pan No.:

AABPV2441B

PAN:

00383945

 

 

Name :

Mr. Hasmukh Ch. Shah

Designation :

Director

Address :

7 A , Saahil , 14 Altamount Road , Mumbai 400026 , Maharashtra  India

Tel No.:

91-22-2351993

Date of Birth/Age :

18.06.1931

Pan No.:

0013818

Date of Appointment :

24.02.2006

 

 

KEY EXECUTIVES

 

Name :

Dr. Chetan Tamhankar , Ph. D

Designation :

Chief Operating Officer

 

 

Name :

Priya Pawar

Designation :

Head – Business Development

Experience :

6 year

Date of Appointment :

2003

 

 

Name :

Mr. Vishnu Banka

Designation :

Head – Finance & Cost Managements

Qualification :

B.Com , ICWA

Experience :

17 Years.

 

 

Name :

Jayanti Vaiyanath

Designation :

Head – Legal , administration & CTS Management

Qualification :

Master Degree in Law

Date of Appointment :

2001

 

 

Name :

Dr. Nimita

Designation :

Head – Clinical Data Management & Biometrics.

Qualification :

Ph. D

Experience :

11years

 

 

Name :

Rupaal Achrekar.

Designation :

Human Resources

Qualification :

B.Com , MBA in Human Resources

Experience :

13 years.

Name :

Dr. Ashok Ghone , Ph,.D

Designation :

Sr. Manager

 

 

Name :

Nomita Chatterjee, 

Designation :

Sr. Project Manager

Qualification :

MD.

 

 

Name :

Dr. Anand Bidarkar

Designation :

Senior Manager

 

 

Name :

Dr. Aparna Kalsekar , MD

Designation :

Manager – Medical Services

 

 

Name :

Mr. Partha Chatterjee

Designation :

Project Manager

Qualification :

M.Sc

Date of Appointment :

1998

 

 

Name :

MR. Sunil Garg 

Designation :

Manager – Clinical Monitoring

Qualification :

M. Pharm , MBA, RICR

Experience :

35 years

 

 

Name :

Shashikant Bhat

Designation :

Manager – Quality Assurance

 

 

MAJOR SHAREHOLDERS

 

Names of Shareholders

No. of Shares

Percentage of Holding

Gautam V Daftry

20100

 

Bahrat V Daftary

20100

 

Foreign Holding (Foreign institutional investor(s) , Foreign companie(s) Foreign financial institution(s) , Non-resident Indian(s) or overseas corporate bodies or others.

 

29.97%

Directors or relatives od directors

 

70.03%

Total

 

100%

 

 

BUSINESS DETAILS

 

Line of Business :

Commercialisation services provider offering solutions in clinical staffing, biostatistics and data management

 

 

 

GENERAL INFORMATION

 

Bankers :

Not Available

 

 

Auditors :

 

Name :

M.M. Nissim & Company

Chartered Accountants

Address :

Barodawala Mansion , B – Wing , 3rd Flr., 81 , Dr. A.B. Road Worli  Mumbai 400018

Pan No.:

AAAFM5103E

 

 

CAPITAL STRUCTURE

 

Authorised Capital:

No. of Shares

Type

Value

Amount

50000

Equity Shares

Rs. 10/-each

Rs.0.500/-Million

 

Issued, Subscribed & Paid-up Capital:

No. of Shares

Type

Value

Amount

4020

Equity

Rs. 10/- each

Rs.0.040/- Million

 

Issued Share Capital breakup:

No. of Shares

Type

Value

Amount

50000

Equity Shares

Rs. 10/-each

Rs.0.500/-Million

 

 


 

 

FINANCIAL DATA

[all figures are in Rupees Millions]

 

 

ABRIDGED BALANCE SHEET

 

SOURCES OF FUNDS

 

 

31.03.2006

31.03.2005

SHAREHOLDERS FUNDS

 

 

 

1] Share Capital

 

0.521

0.402

2] Share Application Money

 

0.000

0.000

3] Reserves & Surplus

 

161.795

21.720

4] (Accumulated Losses)

 

0.000

0.000

NETWORTH

 

162.316

22.122

LOAN FUNDS

 

 

 

1] Secured Loans

 

0.000

0.000

2] Unsecured Loans

 

2.344

19.253

TOTAL BORROWING

 

2.344

19.253

DEFERRED TAX LIABILITIES

 

0.000

0.889

 

 

 

 

TOTAL

 

164.660

42.264

 

 

 

 

APPLICATION OF FUNDS

 

 

 

 

 

 

 

FIXED ASSETS [Net Block]

 

39.111

20.837

Capital work-in-progress

 

0.000

0.000

 

 

 

 

INVESTMENT

 

0.000

0.000

DEFERREX TAX ASSETS

 

1.330

0.000

 

 

 

 

CURRENT ASSETS, LOANS & ADVANCES

 

 

 

 

Inventories

 

0.307

1.264

 

Sundry Debtors

 

34.943

19.816

 

Cash & Bank Balances

 

87.044

1.398

 

Other Current Assets

 

0.000

0.000

 

Loans & Advances

 

22.283

10.720

Total Current Assets

 

144.577

33.198

Less : CURRENT LIABILITIES & PROVISIONS

 

 

 

 

Current Liabilities

 

17.911

11.211

 

Provisions

 

2.447

0.560

Total Current Liabilities

 

20.358

11.771

Net Current Assets

 

124.219

21.427

 

 

 

 

MISCELLANEOUS EXPENSES

 

0.000

0.000

 

 

 

 

TOTAL

 

164.660

42.264

 


PROFIT & LOSS ACCOUNT

 

PARTICULARS

 

 

31.03.2006

31.03.2005

Sales Turnover

 

154.986

110.899

Total Income

 

154.986

110.899

 

 

 

 

Profit/(Loss) After Tax

 

23.646

5.350

 

 

 

 

Earnings in Foreign Currency :

 

 

 

Total Earnings

 

74.558

59.007

 

 

 

 

Expenditures :

 

 

 

 

Interest

 

2.687

2.244

 

Depreciation & Amortization

 

5.247

3.728

 

Other Expenditure

 

123.406

99.576

Total Expenditure

 

131.340

105.548

 

 

 

KEY RATIOS

 

PARTICULARS

 

 

 

31.03.2006

31.03.2005

PAT / Total Income

(%)

 

15.25

4.82

 

 

 

 

 

Debt Equity Ratio

(Total Liability/Networth)

 

 

0.12

0.53

 

 

 

 

 

Current Ratio

(Current Asset/Current Liability)

 

 

7.10

2.82

 

 

LOCAL AGENCY FURTHER INFORMATION

 

Web Site Details Attached:

 

Dr. Chetan Tamhankar, Ph.D
Chief Operating Officer

 

Dr. Chetan Tamhankar, a Ph.D by qualification and has been instrumental right from the inception of SIRO. He has been associated with SIRO since the early years and he has steered the company to its current No. 1 position in the Indian clinical research industry.

Dr. Tamhankar oversees the entire operations of SIRO across the various departments. In addition to his role as COO, Dr. Tamhankar is also an important member of the steering committee of the Indian Society of Clinical Research (ISCR) and a highly sought-after guest speaker at the Academy of Clinical Excellence (ACE) in Mumbai.

 

Priya Pawar
Head - Business Development

 

Ms. Priya Pawar has been with SIRO since 2003 and was instrumental in leading the CAGR of 100% in the last 3 years. With an MBA in Marketing and 6 years of experience in setting up and leading the business development team for a leading Indian Central Laboratory, Ms. Pawar is now responsible for leading the Business Development and Feasibility teams to make SIRO Clinpharm the No. 1 CRO of choice in both the domestic as well as the global markets.

 

Mr. Vishnu Banka
Head - Finance & Cost Management

 

Mr. Vishnu Banka is a B.Com, ICWA with over 17 years of industry experience in finance, accounts and costing. His professional expertise ranges from the Automobiles to Healthcare. Having worked extensively with the Mahindra group, he has gained valuable insights into the SME & ERP consultancy from the USA

 

Jayanti Vaidyanath
Head - Legal, Administration & CTS Management

 

Ms. Jayanti Vaidyanath holds a Masters degree in Law and has been with SIRO since 2001 managing several key functions in the company. Currently, Ms. Vaidyanath advises on all legal contracts and agreements besides overseeing all administrative functions for SIRO. Her portfolio also includes overseeing the functioning of the Clinical Trial Supplies Management group and guiding its operations and growth.

 

Dr. Nimita Limaye, Ph.D
Head - Clinical Data Management & Biometrics

 

Dr. Nimita Limaye is a Doctorate in Biotechnology from Pune University with eleven years of work experience. She also carries the unique distinction of being the first Indian Certified Clinical Data Manager from SCDM, USA. She has received international training in Data management, programming and medical writing. Dr. Limaye has held pivotal positions in Altana Pharma and Quintiles India. She currently leads a team of 150 professionals in the areas of data management and biometrics.

 

Dr. Ashok Ghone, Ph.D
Sr. Project Manager

 

Dr. Ashok Ghone has a doctorate in Pharmaceutical Sciences and has close to 9 years of experience in clinical monitoring, project management and regulatory activities from leading multinational companies like Janssen-Cilag in India. He is currently supervising the Indian arm of global studies in areas like CNS, Rheumatology and Vaccines for several US-based and EU-based pharmaceutical companies.

Nomita Chatterjee, MD
Sr. Project Manager

 

Dr. Nomita Chatterjee has an MD in Pharmacology from Delhi University. She has previously held senior positions in Clinical Operations for leading pharmaceutical companies like Ranbaxy and CROs like Wellquest for close to eight years. Apart from being the Senior Project Manager,
Dr. Chatterjee is also a key member of the Project Risk Assessment and Management (PRAM) group in SIRO, which is an important advisory group to Project Managers across all projects.

 

Dr. Anand Bidarkar
Senior Manager

 

Dr. Anand Bidarkar is a dental surgeon with an executive Masters in Business Administration. He has 7 years of experience across a wide range of areas in the healthcare industry. He started his career with Apollo Hospitals, and has worked with Sun Pharmaceuticals and Novartis group before joining SIRO. He has undergone extensive training in Health informatics and healthcare marketing. He has a rich managerial background and has trained on the Manage Mentor program, for new age managers, from the Harvard Business School during his stint with Novartis.

 

Dr. Aparna Kalsekar, M.D
Manager - Medical services

 

Dr. Aparna Kalsekar has done her M.D. in Microbiology. She has held pivotal positions in the industry as well as in academia. She embarked on her professional journey as a lecturer with the Lokmanya Tilak Municipal Medical College and Hospital, Sion and has worked with renowned firms like Alkem laboratories. She currently leads the Medical Services department which looks into medical and safety management.

 

Mr. Partha Chatterjee M. Sc
Project Manager

 

Armed with a Masters Degree in Microbiology from Aurangabad University, Mr. Chatterjee began his career in clinical research as a CRA in the Clinical Operations team in SIRO in 1998. Since then, Partha has moved on to become one of SIRO’s oldest employees and one of our key Project Managers with a diverse portfolio of clinical trials in oncology and rheumatology.

 

Mr. Sunil Garg M. Pharm, MBA, RICR
Manager - Clinical Monitoring

 

Sunil Garg is post graduate in pharmaceuticals from Delhi University and also holds a degree in management. He has five years of experience in CRO operations with a leaning towards clinical research training. He currently leads a team of more than 35 professionals in the area of clinical monitoring at SIRO.

 

Shashikant Bhat
Manager - Quality Assurance

 

Mr. Shashikant Bhat heads Quality Assurance and is responsible for ensuring compliance within the company to ICH GCP and the SIRO SOPs.

The QA group has contributed to SIRO’s success in all the sponsor audits. Mr. Bhat has built a team of QA professionals that is proficient in conducting investigator sites, data management and vendor audits for clients. Mr. Bhat also serves as faculty and has held several workshops on clinical research and quality assurance audits for academics as well as sponsored QA teams.

 

Location

 

SIRO Clinpharm is headquartered in Mumbai, the financial capital of India, and the heart of the Indian pharmaceutical industry. Situated on the outskirts of Mumbai, SIRO is well-connected to the city and the major domestic and international airports by a robust Eastern Express Highway

 

Located in Thane, it is away from the hustle-and-bustle of the city and yet remains well connected by virtue of it being a rapidly developing district of Mumbai. SIRO’s offices are spread over 40,000 square feet of space allowing for a very conducive work environment.

 

Milestones

 

From its very inception, SIRO has evolved as an organisation. It has grown both in size as well as in scope and today offers specialized services in different areas of clinical research. With each passing year, SIRO has added to its capabilities.

 

Alliances


The SIRO-Pfizer Clinical Data Management and Biometrics Pact


Pfizer, the world’s leading pharmaceutical company, needs little by way of introduction. In May 2004, Pfizer and SIRO Clinpharm announced a pact wherein SIRO would provide complete data management and biometrics services for all of Pfizer’s global clinical trials run worldwide. SIRO has set up a separate facility with resources dedicated to this project, all of which are equipped to deliver according to Pfizer standards.This was a significant acheivement for SIRO.

SIRO & Covance

 

Covance is one of the world’s largest and the most comprehensive drug development solution providers. It has the people, global resources and problem-solving culture to respond to even the most demanding challenges of drug development services. SIRO entered into an alliance with Covance in 2003 to offer the “India” advantage to global pharmaceutical companies for their drug development programs, while providing Indian companies with global expertise.

 

SIRO & Spacelabs Medical Data


Spacelabs Medical Data is a leading US-based global cardiac safety monitoring service provider. It has formed a strategic alliance with SIRO Clinpharm in December 2004. The alliance aims at providing companies conducting trials in India with centralized cardiac safety monitoring services (viz. 12 lead ECG, Holter monitoring, Ambulatory Blood Pressure monitoring etc.)

 

SIRO and Fisher Clinical Services


Fisher Clinical Services is a global drug distribution and warehousing company with operations spread across 18 countries. The expertise of the global clinical trial supply distribution has now extended to India via SIRO Clinpharm. Its alliance with SIRO has allowed Fisher to tap the vast resources available in India. SIRO functions as the Indian depot, providing warehousing and distribution services to Fishers’ clients who conduct clinical trials in India.

 

InVentiv-SIRO (India) Ltd.


inVentiv Clinical Solutions is a leading US-based pharmaceutical commercialisation services provider offering solutions in clinical staffing, biostatistics and data management. This joint venture offers the double benefits of inVentiv’s broad statistical analysis, data management services and premier client portfolio and SIRO’s expertise in conducting large-scale Phase II – IV clinical trial data management projects. InVentiv-SIRO (India) will provide pharmaceutical and biotech companies access to a broad pool of offshore talent who will design databases, conduct data and statistical analysis. This joint venture is also capable of providing large-scale off-shore services to fulfill clinical data management and biometrics requirements in a manner that is both time as well as cost-effective.

 

Indian Society for Clinical Research (ISCR)


ISCR is an association of clinical research. It aims to build awareness of clinical research as a speciality in India and promote Good Clinical Practices in the clinical research industry. SIRO has been involved in the foundation of this society and is part of its steering committee. Being one of the oldest players in the clinical research sector in India, our association with such societies adds credibility and value to their aims.

 

 

Confederation of Indian Industry (CII)

 

The CII works to create and sustain an environment conducive to the growth of industry in India, partnering industry and government alike through advisory and consultative processes. CII is a
non-government, not-for-profit, industry-led and industry-managed organization, playing a proactive role in India’s development process. A facilitator, CII catalyses change by working closely with government on policy issues, enhancing efficiency, competitiveness and expanding business opportunities for industry through a range of specialized services and global linkages.

 

SIRO is a key opinion leader in the Clinical Research industry with more than 10 years of experience is a valuable member of CII. The extremely valued insights that SIRO offers in such confederations have helped take the clinical research industry to its present heights.

 

 

Academy for Clinical Excellence (ACE)

 

ACE is a premier institute which provides training in clinical research in India. Founded in October 2002 at the Bombay College of Pharmacy, ACE was conceived as a one-stop-shop for all the training needs of clinical research professionals across the country.

 

SIRO has been instrumental in designing the curricula of these institutes. The senior management from SIRO is often invited as guest faculty to deliver presentations on a range of topics.

 


CMT REPORT (Corruption, Money Laundering & Terrorism]

 

The Public Notice information has been collected from various sources including but not limited to: The Courts, India Prisons Service, Interpol, etc.

 

1]         INFORMATION ON DESIGNATED PARTY

No records exist designating subject or any of its beneficial owners, controlling shareholders or senior officers as terrorist or terrorist organization or whom notice had been received that all financial transactions involving their assets have been blocked or convicted, found guilty or against whom a judgement or order had been entered in a proceedings for violating money-laundering, anti-corruption or bribery or international economic or anti-terrorism sanction laws or whose assets were seized, blocked, frozen or ordered forfeited for violation of money laundering or international anti-terrorism laws.

 

2]         Court Declaration:

No records exist to suggest that subject is or was the subject of any formal or informal allegations, prosecutions or other official proceeding for making any prohibited payments or other improper payments to government officials for engaging in prohibited transactions or with designated parties.

 

3]         Asset Declaration:

No records exist to suggest that the property or assets of the subject are derived from criminal conduct or a prohibited transaction.

 

4]         Record on Financial Crime:

            Charges or conviction registered against subject:                                                  None

 

5]         Records on Violation of Anti-Corruption Laws:

            Charges or investigation registered against subject:                                                          None

 

6]         Records on Int’l Anti-Money Laundering Laws/Standards:

            Charges or investigation registered against subject:                                                          None

 

7]         Criminal Records

No available information exist that suggest that subject or any of its principals have been formally charged or convicted by a competent governmental authority for any financial crime or under any formal investigation by a competent government authority for any violation of anti-corruption laws or international anti-money laundering laws or standard.

 

8]         Affiliation with Government :

No record exists to suggest that any director or indirect owners, controlling shareholders, director, officer or employee of the company is a government official or a family member or close business associate of a Government official.

 

9]         Compensation Package :

Our market survey revealed that the amount of compensation sought by the subject is fair and reasonable and comparable to compensation paid to others for similar services.

 

10]        Press Report :

            No press reports / filings exists on the subject.

 

 

CORPORATE GOVERNANCE

 

MIRA INFORM as part of its Due Diligence do provide comments on Corporate Governance to identify management and governance. These factors often have been predictive and in some cases have created vulnerabilities to credit deterioration.

 

Our Governance Assessment focuses principally on the interactions between a company’s management, its Board of Directors, Shareholders and other financial stakeholders.

 

 

CONTRAVENTION

 

Subject is not known to have contravened any existing local laws, regulations or policies that prohibit, restrict or otherwise affect the terms and conditions that could be included in the agreement with the subject.

 

 

FOREIGN EXCHANGE RATES

 

Currency

Unit

Indian Rupees

US Dollar

1

Rs.42.87

UK Pound

1

Rs.84.79

Euro

1

Rs.57.56

 

 

SCORE & RATING EXPLANATIONS

 

SCORE FACTORS

 

RANGE

POINTS

HISTORY

1~10

5

PAID-UP CAPITAL

1~10

5

OPERATING SCALE

1~10

5

FINANCIAL CONDITION

 

 

--BUSINESS SCALE

1~10

7

--PROFITABILIRY

1~10

4

--LIQUIDITY

1~10

6

--LEVERAGE

1~10

6

--RESERVES

1~10

6

--CREDIT LINES

1~10

6

--MARGINS

-5~5

-

DEMERIT POINTS

 

 

--BANK CHARGES

YES/NO

Yes

--LITIGATION

YES/NO

NO

--OTHER ADVERSE INFORMATION

YES/NO

NO

MERIT POINTS

 

 

--SOLE DISTRIBUTORSHIP

YES/NO

NO

--EXPORT ACTIVITIES

YES/NO

YES

--AFFILIATION

YES/NO

YES

--LISTED

YES/NO

NO

--OTHER MERIT FACTORS

YES/NO

YES

TOTAL

 

50

 

This score serves as a reference to assess SC’s credit risk and to set the amount of credit to be extended. It is calculated from a composite of weighted scores obtained from each of the major sections of this report. The assessed factors and their relative weights (as indicated through %) are as follows:

 

Financial condition (40%)            Ownership background (20%)                 Payment record (10%)

Credit history (10%)                    Market trend (10%)                                Operational size (10%)

 


 

RATING EXPLANATIONS

 

RATING

STATUS

 

 

PROPOSED CREDIT LINE

>86

Aaa

Possesses an extremely sound financial base with the strongest capability for timely payment of interest and principal sums

 

Unlimited

71-85

Aa

Possesses adequate working capital. No caution needed for credit transaction. It has above average (strong) capability for payment of interest and principal sums

 

Large

56-70

A

Financial & operational base are regarded healthy. General unfavourable factors will not cause fatal effect. Satisfactory capability for payment of interest and principal sums

 

Fairly Large

41-55

Ba

Overall operation is considered normal. Capable to meet normal commitments.

 

Satisfactory

26-40

B

Unfavourable & favourable factors carry similar weight in credit consideration. Capability to overcome financial difficulties seems comparatively below average/normal.

 

Small

11-25

Ca

Adverse factors are apparent. Repayment of interest and principal sums in default or expected to be in default upon maturity

 

Limited with full security

<10

C

Absolute credit risk exists. Caution needed to be exercised

 

 

Credit not recommended

NR

In view of the lack of information, we have no basis upon which to recommend credit dealings

No Rating

 

PRIVATE & CONFIDENTIAL : This information is provided to you at your request, you having employed MIPL for such purpose. You will use the information as aid only in determining the propriety of giving credit and generally as an aid to your business and for no other purpose. You will hold the information in strict confidence, and shall not reveal it or make it known to the subject persons, firms or corporations or to any other. MIPL does not warrant the correctness of the information as you hold it free of any liability whatsoever. You will be liable to and indemnify MIPL for any loss, damage or expense, occasioned by your breach or non observance of any one, or more of these conditions