MIRA INFORM REPORT

 

 

Report Date :

27.05.2011

 

IDENTIFICATION DETAILS

 

Name :

AVESTHAGEN LIMITED

 

 

Registered Office :

Unit 3, Discoverer, 9th Floor, International Tech Park, Whitefield Road, Bangalore – 560066, Karnataka

 

 

Country :

India

 

 

Financials (as on) :

31.03.2010

 

 

Date of Incorporation :

20.04.1998

 

 

Com. Reg. No.:

01-030671

 

 

Capital Investment / Paid-up Capital :

Rs.45.553 Millions

 

 

CIN No:

U73100KA1998PLC030671

 

 

TAN No.:

[Tax Deduction & Collection Account No.]

BLRA06507E

 

 

PAN No.:

[Permanent Account No.]

AABCA7217K

 

 

Legal Form :

A Closely held Public Limited Liability Company

 

 

Line of Business :

The Company is a leading life science company pioneering the convergence between food, pharma  and populations genetics leading to predictive preventive personalized  Healthcare.

 

RATING & COMMENTS

 

MIRA’s Rating :

B (33)

 

RATING

STATUS

PROPOSED CREDIT LINE

26-40

B

Capability to overcome financial difficulties seems comparatively below average.

Small

 

Maximum Credit Limit :

USD 3090000

 

 

Status :

Moderate

 

 

Payment Behaviour :

Slow

 

 

Litigation :

Clear

 

 

Comments :

Subject is an established company having moderate track. Profitability of the company appears to be under pressure. There appears to be some accumulated losses recorded by the company. However, trade relations are reported as fair. Payments are reported to be slow.

 

The company can be considered for business dealings with some caution.

 

NOTES :

Any query related to this report can be made on e-mail : infodept@mirainform.com while quoting report number, name and date.

 

 

ECGC Country Risk Classification List – April 1, 2010

 

Country Name

Previous Rating

(31.12.2009)

Current Rating

(01.04.2010)

India

A1

A1

 

Risk Category

ECGC Classification

Insignificant

 

A1

Low

 

A2

Moderate

 

B1

High

 

B2

Very High

 

C1

Restricted

 

C2

Off-credit

 

D

 

 

 

 

LOCATIONS

 

Registered Office :

Unit 3, Discoverer, 9th Floor, International Tech Park, Whitefield Road, Bangalore – 560066, Karnataka, India

Tel. No.:

91-80-28411665/28412308/28412770/28412766

Fax No.:

91-80-28418780

E-Mail :

info@avesthagen.com

villoo@avesthagen.com

Website :

www.avesthagen.com

 

 

Branch Office 1 :

Business Centre, 22 Tower B, Logix Techno Park, Sector 127, Noida – 201301, India

Tel. No.:

91-120-4393000

Fax No.:

91-120-4393094

 

 

Branch Office 2 :

Shapoorji Pallonji Biotech Park, Admin. Building, Phase I, Genome Valley, Turkapally Village, Shamirpet Mandal, Ranga Reddy District – 500078, Andhra Pradesh, India

Tel. No.:

91-40-30588012/30588013

Fax No.:

91-40-30588014

 

 

Overseas Office 1 :

Avesthagen M-E FZ-LLC, Office No.113,114 Dubiotech Business Center, Academic City, Dubai, UAE

Tel. No.:

971-506445324/43756734/43756735

Fax No.:

971-43604899/43551901

 

 

Overseas Office 2 :

Avesthagen Pte. Limited, 50 Raffles Place # 17-01, Singapore 048623

Tel. No.:

65-65322122

Fax No.:

65-65320122

 

 

Overseas Office 3 :

Avesthagen Inc., 9588, Topanga Canyon Blvd. Chatsworth, CA 91311, USA

Tel. No.:

818-709-2411

Fax No.:

818-709-2414

Web :

www.avesthagen.com/usa/

 

 

DIRECTORS

 

AS ON 20.08.2010

 

Name :

Mr. Villoo Morawala Patel

Designation :

Chairman Cum Managing Director

Address :

No.8A, Regency Heights, No.3, Cleaveland Road, Frazer Town, Bangalore-560005, India

Date of Birth/Age :

18.06.1955

Date of Appointment :

20.04.1998

DIN No :

01692908

 

 

Name :

Mr.Koenraad Jan Wentink

Designation :

Director

Address :

Windsor Villa Appartment No.589, Defence Colony, 2nd Main, 2nd Cross, Indira Nagar – 560038

Date of Birth/Age :

19.11.1964

Date of Appointment :

06.02.1999

DIN No :

01732163

 

 

Name :

Mr. Marc Van Montagu

Designation :

Director

Address :

University of Ghent, Lebeganchstraat-35, Labo Gentika Belgium

Date of Birth/Age :

10.11.1933

Date of Appointment :

23.03.1999

DIN No :

01907873

 

 

Name :

Ms. Farah Patell Socha

Designation :

Director

Address :

No.8A, Regency Heights No.3, Cleaveland Road, Frazer Town, Bangalore – 560005

Date of Birth/Age :

02.07.1981

Date of Appointment :

27.06.2005

DIN No :

01739131

 

 

Name :

Ms. Sanaya Morawala Patell

Designation :

Director

Address :

No. 8A, Regency Heights, No. 3, Cleaveland Road, Frazer Town – 560005, Bangalore, India

Date of Birth/Age :

01.10.1983

Date of Appointment :

21.01.2008

DIN No :

02023602

 

 

Name :

Mr. John Darbyshire

Designation :

Additional Director

Address :

Rte de Fenil, 16 A, 1806 St Legier-La Chiesaz

Date of Birth/Age :

02.07.1948

Date of Appointment :

21.01.2010

DIN No :

02859853

 

 

Name :

Mrs. Dominique Takizawa

Designation :

Additional Director

Address :

17 rue Vaucanson, Lyon 69001, France

Date of Birth/Age :

12.07.1956

Date of Appointment :

17.02.2010

DIN No :

02704660

 

 

Name :

Mr. Christophe Paul Bowler

Designation :

Additional Director

Address :

21, Avenue De Suffren Paris – 75007 NA France

Date of Birth/Age :

23.02.1965

Date of Appointment :

31.03.2010

DIN No :

02948584

 

 

Name :

Mr. Narayan K Sesadhri

Designation :

Additional Director

Address :

Flat No.91, 9th Floor, Everest Co-operative Housing Society, MT. Pleasant Road, Malabar Hill, Mumbai – 400006, Maharashtra, India

Date of Birth/Age :

13.04.1957

Date of Appointment :

29.06.2010

DIN No :

00053563

 

 

Name :

Mr. Jaques Francois Alexandre Vincent

Designation :

Additional Director

Address :

15 RUE Theodule Ribot Paris 75017

Date of Birth/Age :

09.04.1946

Date of Appointment :

29.06.2010

DIN No:

02675669

 

 

MAJOR SHAREHOLDERS / SHAREHOLDING PATTERN

 

AS ON 20.08.2010

 

Names of Shareholders

No. of Shares

Villoo Morawala Patel

1650294

Koenraad Jan Wentink

246416

Christophe Paul Bowler

1573

 

 

AS ON 20.08.2010

 

Category

Percentage

Venture Capital

13.27

Foreign holdings( Foreign institutional investor(s), Foreign companie(s) Foreign financial institution(s), Non-resident Indian(s) or Overseas Corporate bodies or Others

                       38.90

Bodies corporate

14.82

Directors or relatives of Directors

29.66

Other

3.35

Total

100.00

 

 

BUSINESS DETAILS

 

Line of Business :

The Company is a leading life science company pioneering the convergence between food, pharma  and populations genetics leading to predictive preventive personalized  Healthcare.

 

 

GENERAL INFORMATION

 

Bankers :

Not Available

 

 

Facilities :

 

Secured Loan

 

Rs. In Millions

31.03.2010

Rs. In Millions

31.03.2009

Debentures

354.400

420.000

Interest accrued and due on above

0.000

0.526

Term Loans from Banks

371.378

219.719

Interest accrued and due on above

2.526

2.689

Term  Loan from Citicorp Finance (India) Limited

110.000

160.000

Interest accrued and due on above

10.950

4.099

Cash Credit facilities from bank

0.000

156.802

Total

849.254

963.835

 

 

 

Unsecured Loan

 

Rs. In Millions

31.03.2010

Rs. In Millions

31.03.2009

Term Loans from Banks

18.400

18.400

Interest accrued and due on above

1.104

0.000

Term Loans from Council for Scientific and Industrial Research (CSIR)

27.315

27.315

Interest accrued and due on above

                         3.807

1.949

Term Loans from Department of Biotechnology (DBT)

5.000

0.000

Short term loan from a Company

0.000

100.000

Interest accrued and due on above

0.000

10.769

Total

55.626

158.433

 

 

 

Banking Relations :

--

 

 

Auditors :

 

Name :

S.R. Batliboi and Associates

Chartered Accountant

Address :

UB City 24, Vital Mallya Road, Bangalore – 560001, India

PAN No.:

AABFS3421N

 

 

Name :

Agarwal and Italia

Chartered Accountant

Address :

Suite “H”, Fifth Floor, Surya Towers, Sardar Patel Road, Secunderabad -500003, Andhra Pradesh, India

                              PAN No.:

AAGFS7350F

 

 

Subsidiary Company :

Name of the Company :  Avesthagen Research Private Limited

CIN No.: U73100KA2004PTC034247   

 

 

 

Name of the Company : Avestagenome Project International Private Limited

CIN No.: U73100KA2007PTC044724

 

 

 

Name of the Company : Avesthagen Quality Agriculture Services Private Limited

CIN No .: U01119AP2003PTC041571

Adress : Discoverer, 9th Floor, International Technology Park, Whitefield Road, Bangalore 560066, India

Telephone No.: 91-80-28411665 / 2308 / 2770 / 2766

Fax No: 91-80-28418780

Web : www.aquasltd.com

 

 

 

Name of the Company : Ava Seeds Private Limited

CIN No.: U01403KA2007PTC042404

 

 

 

Name of the Company : Swagath Seeds Private Limited

CIN No.: U01119AP1999PTC031422

 

 

 

Name of the Company : Dhanvantaru Botanicals Private Limited

CIN No.: U51909KA1995PTC017430

Address : #593 10th Cross, 7th main, JP Nagar, 3rd Phase, Bangalore 560078, India

Telephone No: 91-80-26591529

Fax No : 91-80-26596062

 

 

 

Name of the Company : Avesta Good Earth Foods Private Limited

CIN No.: U01549KA2005PTC036627

Address : Discoverer, 9th Floor, International Technology Park, Whitefield Road, Bangalore 560066, INDIA

Telephone No: 91-80-28411665/2308/2770/2766

Fax No.: 91-80-2841 8780

 

 

 

Name of the Company : Avesta Nordic Research Private Limited (ANRPL)

Adress : Discoverer, 9th Floor, International Technology Park, Whitefield Road, Bangalore 560066, India

Telephone No: 91-80-28411665 / 2308 / 2770 / 2766

Fax No.: 91-80-28411665 / 2308 / 2770 / 2766

 

 

 

Name of the Company : Avesta Middleeast FZ-LLC

 

 

 

Name of the Company : Avesthagen Private Limited

 

 

 

Name of the Company : Avesthagen Inc.

 

 

Joint Venture:

Atash Seeds Private Limited, India

Address : Discoverer, 9th Floor, International Technology Park, Whitefield Road, Bangalore 560066, Karnataka, India

 

Avesta Biotherapeutics and Research Private Limited (ABRPL)

Address : Discoverer, 9th Floor, International Technology Park, Whitefield Road, Bangalore 560066, Karnataka, India

 

Avesta Biotherapeutics and Research Private Limited, Singapore (ABRS)

 

Swagath Seeds Private Limited, India

 

Ava Seed Private Limited, India

 

 

 

CAPITAL STRUCTURE

 

AS ON 31.03.2010

 

Authorised Capital :

No. of Shares

Type

Value

Amount

 

 

 

 

10000000

Equity Shares

Rs.10/- each

Rs.100.000 Millions

 

Issued, Subscribed & Paid-up Capital :

No. of Shares

Type

Value

Amount

 

 

 

 

4555296

Equity Shares

Rs.10/-each

Rs.45.553 Millions

 

Notes :

 

1. Of the above, 2401 equity shares were allotted pursuant to a contract for consideration other than cash.

 

 

AS ON 20.08.2010

 

Authorised Capital :

No. of Shares

Type

Value

Amount

 

 

 

 

20000000

Equity Shares

Rs.7/- each

Rs.140.000 Millions

 

Issued, Subscribed & Paid-up Capital :

No. of Shares

Type

Value

Amount

 

 

 

 

6524947

Equity Shares

Rs.10/-each

Rs.45.674 Millions

 

 

 

 

FINANCIAL DATA

[all figures are in Rupees Millions]

 

ABRIDGED BALANCE SHEET

 

SOURCES OF FUNDS

 

31.03.2010

31.03.2009

31.03.2008

SHAREHOLDERS FUNDS

 

 

 

1] Share Capital

45.553

42.541

42.113

2] Share Application Money

5.126

25.085

10.614

3] Reserves & Surplus

764.998

377.776

1653.788

4] (Accumulated Losses)

(42.186)

0.000

(306.054)

NETWORTH

773.491

445.402

1400.461

LOAN FUNDS

 

 

 

1] Secured Loans

849.255

963.836

759.583

2] Unsecured Loans

55.626

158.433

46.545

TOTAL BORROWING

904.881

1122.269

806.128

DEFERRED TAX LIABILITIES

0.000

0.000

0.000

Others

 

 

 

Stock Options Outstanding

5.064

2.743

2.061

TOTAL

1683.436

1570.414

2208.650

 

 

 

 

 

 

APPLICATION OF FUNDS

 

 

 

 

 

 

 

FIXED ASSETS [Net Block]

634.542

618.385

460.354

Capital work-in-progress

15.366

11.232

101.042

 

 

 

 

INVESTMENT

548.635

479.106

455.631

DEFERREX TAX ASSETS

0.000

0.000

0.000

 

 

 

 

CURRENT ASSETS, LOANS & ADVANCES

 

 

 

 

Inventories

10.021

20.877

26.648

 

Sundry Debtors

328.943

330.650

371.186

 

Cash & Bank Balances

24.314

7.730

158.357

 

Other Current Assets

1.058

5.845

6.025

 

Loans & Advances

                      611.694

595.776

777.452

Total Current Assets

976.030

960.878

1339.668

Less : CURRENT LIABILITIES & PROVISIONS

 

 

 

Sundry Creditors

234.932

295.488

 

 

Other Current Liabilities

45.099

51.462

138.192

 

Provisions

211.106

152.237

9.853

Total Current Liabilities

491.137

499.187

      148.045

Net Current Assets

484.893

461.691

1191.623

 

 

 

 

MISCELLANEOUS EXPENSES

0.000

0.000

0.000

 

 

 

 

TOTAL

1683.436

1570.414

2208.650

PROFIT & LOSS ACCOUNT

 

 

PARTICULARS

31.03.2010

31.03.2009

31.03.2008

 

SALES

 

 

 

 

 

Income

338.685

88.763

332.307

 

 

Other Income

23.506

20.174

84.063

 

 

TOTAL                                (A)

362.191

108.937

416.370

 

 

 

 

 

Less

EXPENSES

 

 

 

 

 

Cost of Traded Goods

0.000

8.887

0.000

 

 

Consumption of Chemicals and Consumables

15.600

37.873

45.115

 

 

Employee Costs

122.762

192.345

162.433

 

 

Administration, Selling and other Expenses

164.466

225.596

232.732

 

 

Amortization

9.351

9.866

19.476

 

 

TOTAL                         (B)

312.179

474.567

459.756

 

 

 

 

 

Less

PROFIT BEFOREINTEREST,TAX, DEPRECIATION AND AMORTISATION (A-B)            I

50.012

 

(365.630)

(43.386)

 

 

 

 

 

Less

FINANCIAL EXPENSES             (D)

71.894

86.947

67.566

 

 

 

 

 

 

PROFIT BEFORE TAX, DEPRECIATION AND AMORTISATION (C-D)                           (E)

(21.882)

(452.577)

(110.952)

 

 

 

 

 

Less/ Add

DEPRECIATION/ AMORTISATION                 (F)

19.220

22.199

27.658

 

 

 

 

 

 

PROFIT BEFORE TAX (E-F)                         (G)

(41.102)

               (474.776)

(138.610)

 

 

 

 

 

Less

TAX                                                              (I)

1.084

6.200

2.601

 

 

 

 

 

 

PROFIT AFTER TAX (G-I)                             (J)

(42.186)

(480.976)

(141.211)

 

 

 

 

 

Add

PREVIOUS YEARS’ BALANCE BROUGHT FORWARD

0.000

(306.054)

(164.843)

Less

Adjusted with Securities Premium Account

                     0.000

(787.030)

(306.054)

 

Loss end of the year

(42.186)

0.000

(306.054)

 

Earnings Per Share (Rs.)

 

 

 

 

Basic and Diluted

(9.86)

(113.55)

(33.64)

 

 

KEY RATIOS

 

PARTICULARS

 

 

31.03.2010

31.03.2009

31.03.2008

PAT / Total Income

(%)

(11.64)

(441.51)

(33.91)

 

 

 

 

 

Net Profit Margin

(PBT/Sales)

(%)

(12.13)

(534.88)

(41.71)

 

 

 

 

 

Return on Total Assets

(PBT/Total Assets}

(%)

(2.55)

(30.06)

(7.70)

 

 

 

 

 

Return on Investment (ROI)

(PBT/Networth)

 

(0.05)

(1.06)

(0.09)

 

 

 

 

 

Debt Equity Ratio

(Total Liability/Networth)

 

1.80

3.64

0.68

 

 

 

 

 

Current Ratio

(Current Asset/Current Liability)

 

                    1.98

1.92

9.04

 

 

LOCAL AGENCY FURTHER INFORMATION

 

Review of Operations:

 

Avesthagen Limited’s income stood at Rs. 362.19 million (~ USD 6.94 million) as on 31st March 2010, compared to Rs. 108.94 million (~USD 2.32 million). Avesthagen continues to invest in research and product development, the costs for which have to be largely expensed through the Profit and Loss account as per the accounting standards. The company continued with its pharmaceutical product development resulting in an expenditure linked loss of 0.8 million USD as against a net loss. A rich portfolio of products and assets are the outcome of these expenditures and will contribute to significant mid-term cash flow and in the short term enhance the valuation of their company.

 

Following the deferral of the IPO of the company in October 2008 as a consequence of the worst global financial crisis in almost 80 years, the company had to implement a turn-around strategy of raising funds from new sources, reducing costs and rescheduling debt obligations. The following is a brief summary of the achievements in this respect subsequent to the ones already reported to the shareholders in the previous year’s Director’s Report:

 

* equity investment of approx. Rs. 360 million (~USD 7.66 million) from Eternity VMP Holdings, France, an entity owned by Dr. Villoo Morawala-Patell. This transaction closed in March 2010. Part of the funds were used to repay certain pressing debts as a consequence of which the “Loan Funds” as on the 31st March 2010 balance sheet stand reduced correspondingly.

 

A big milestone achievement was the licensing of the Environment Adjusted Crops technology to Vilmorin and Cie resulting in a revenue of 5 million Euros. The deal would also result in the long term revenues through royalties of 5-15% from seeds sold using this technology.

 

  • following partial repayment on 31st march 2010 of the principal amount due under its debenture, the India Advantage Fund (managed by ICICI Ventures) had kindly agreed to write off the pending interest and redemption premium on the repaid principle amount, as well as to reschedule the maturity date to March 2011.

 

  • a similar arrangement was simultaneously agreed with the Emerging Sectors Fund (managed by ICICI Ventures) for its debenture.

 

Government Grants / Softloans

 

Avesthagen Science Team was successful in peer reviewed grants to the tune of Rs. 104 million (~USD 2.21 M).

 

  1. DBT- SBIRI Grant of Rs. 6.5 million was awarded in December 2009 for Project – Heaptocyte-like cells generated from Human embryonic stem cells (hESCs) for Hepatotoxcity screening of Xenobiotics in Drug discovery process

 

  1. DBT-BIPP Grant of Rs. 15 million in November 2009 for Project – Development of Self-Glucogenic Pearl Millet for production

 

 

  1. National Medicinal Plant Board grant of Rs. 2.5 million in 2009 for Project – Pharmacognostivc and Scientific Dossier preparation of selected Rare and Endangered and Threatened (RET) Medicinal Plants

 

 

  1. DBT-SIBRI grant of Rs.40 million in 2010 for Project – Development and Commercialization of a High Value Biosimilar Product aimed at providing cost effective healthcare solution to emerging markets (Etanercept)

 

 

  1. DST-DPRP funding grant of Rs. 40 million in January 2010 for Project – Clinical Study of Efficacy and Safety of Darbepoetin alfa (AVDESP™) for correction of Anemia in Chronic Kidney Disease and Chemotherapy –induced Anemia patients – an Equivalence study

 

 

Contingent Liabilities:

                                                            (Rs. in Millions)

 

2010

2009

a. Bank guarantee to customs authorities/less or

37.795

39.445

b. Income tax matter under appeal

2.146

2.146

c. Guarantee against loan taken by subsidiaries

139.000

141.000

 

d. Customer duty (amount not ascertained) in respect of goods imported duty free under STPI Scheme valuing Rs.254.002 Millions in the prior years. The company has received an order from the Software Technology Parks of India (STPI) for de-bonding of capital has filed an appeal with the STPI authorities. Based on the budgeted revenue plan, the management is confident of discharging export obligation by executing required volume of export in the future period.

 

e. During the year, the company has recognized revenue of Rs.347.17 Million from licensing of intellectually property. Basis, legal opinion, the company is of the view      that aforesaid transaction attracts VAT and service tax is not applicable.

 

f. The company has carried their research services under joint product development contracts with Cipla Limited in prior year till March 31,2009. Based on management’s evaluation and an independent opinion obtained by the company, the company is of the view that there is no service tax payable on such revenues.

 

g. During the year ended March 31,2006, certain fixed assets were purchased and then transferred to ABRPL and hence are not included in fixed assets schedule. The company is in process of de-bonding of such assets. No provision has been made in books of account for custom duty and sales tax liability as the requisite procedural formalities are yet to be complied with. The management plans to recover the taxes from ABRPL as and when paid.

 

Form 8:

Corporate Identity Number (CIN) :

U73100KA1998PLC030671

Name of the company

AVESTHAGEN LIMITED

Address of the registered office or of the principal place of  business in India of the company

Unit 3, Discoverer, 9th Floor, International Tech Park, Whitefield Road, Bangalore-560066, Karnataka, India

E-Mail: viloo@avesthagen.com

This form is for

Creation of charge

Type of charge

Movable property (not being pledge)

Particular of charge holder

Department of Biotechnology, 6-8th Floor, Block No.2, CGO Complex, Lodhi Road, New Delhi-110003, India

Email Id : swarup@dbt.nic.in   

Nature of instrument creating charge

Deed of Hypothecation dated 29th March 2010 read with the original agreement executed between the department of biotechnology and Avesthagen Limited

Date of instrument Creating the charge

29.03.2010

Amount secured by the charge

Rs. 0.400 Million

Brief of the principal terms an conditions and extent and operation of the charge

Rate of interest

2% p.a. upto Rs.100.000 Millions and 3% exceeding Rs. 100.000 Millions

 

Terms of repayment

Ten equal half yearly installments payable one year after closure of the project.

 

Margin

50%

 

Extent and operation of the charge

Any and all equipment, apparatus machineries, machineries, tools and other accessories, goods and or the other moveable property of the borrower, acquired for the project, through contribution by the borrower and bad debt equivalent to Rs.0.400 Million Being the loan sanctioned for no recurring items

Short particulars of the property charged (Including location of the property)

Any and all equipment, apparatus machineries Spares,  tools and other accessories, goods and or the other moveable property of the borrower, acquired for the project

 

The project through contribution by the borrower and by Debt equivalent to Rs.0.400 Million being the loan sanctioned for no recurring items.

 

Fixed Assets:

 

  • Freehold Land
  • Land
  • Building
  • Leasehold Improvements
  • Plant and Machinery
  • Computer
  • Furniture and Fittings
  • Office Equipment

 

WEBSITE DETAILS

 

COMPANY PROFILE

 

Avesthagen is a life science company pioneering the convergence between Food, Pharma and Population Genetics leading to Predictive Preventive Personalized HealthcareTM.

 

The business model of Avesthagen is to combine IP and product development through in-house research and collaborations. Avesthagen has built and continues to build an integrated, systems biology approach of capabilities, products, infrastructure and technology that allows for and facilitates ‘cross talk’ between numerous disciplines, leading to unique and innovative solutions. They employ 450 people worldwide and are headquartered in Bangalore, India.

 

Systems Biology Model. When it comes to discovery and scientific breakthrough they believe in putting together rather than taking apart, integration rather than reduction. The pluralism of causes and effects in biological networks is better addressed by observing, through quantitative measures, multiple components simultaneously and by rigorous data integration and analysis. Systems biology is about looking at one event from different angles; it is about merging sciences at micro and macro levels. It means changing traditional scientific philosophy, in the full sense of the term.

Predictive Preventive Personalized Healthcare. They believe that healthcare will be revolutionized by genomic and stem cell research, becoming predictive, preventive, and personalized. The goal of personalized medicine is, first of all, to use the advanced tools of molecular genetics to predict how patients will respond to drugs, reducing harm and increasing benefit. The dual combination of diagnostic and treatment technologies is at the heart of personalized medicine and will transform healthcare dramatically. They have just entered the world of molecular medicine, and the realities of regenerative medicine and preventative healthcare are within their grasp.

 

Preventive Nutrition

 

The BioNutrition (or Food-for-Medicine) group focuses on developing scientifically validated bioactives from Indian medicinal plants for prevention or treatment of degenerative conditions such as diabetes, obesity, CVD and bone health. They also work on performance enhancement, stress management, skincare, weight management, immunomodulation, pain management, osteoarthritis and digestion through use of proprietary tools. FFM products target both food and pharma markets and, coupled with global marketing strategies and the acquisition of two product driven businesses, the BioNutrition group is poised for sustainable fast growth. It hosts two wholly owned subsidiaries and large collaborative programs. 

 

On the Dietary Supplement front, Avesthagen markets scientifically validated natural ingredients. These set the highest standards for purity and concentration of active constituents. Many of their leading products have strong intellectual proprietary positions. These include trademarks and patents that employ process, composition and method of use claims. Products are manufactured in India and sold in the US and Japan in the form of pills and powders and worldwide though bulk volumes. Europe and south-east Asia will be covered by mid 2009. They have an existing catalogue of over 40 standardized extracts and multiple grades of innovative specialty products and will continue to fuel the pipeline with new products developed in-house or though collaborations.

 

The food wing develops nutritious alternatives for breakfast, daily snacks, and functional foods for all who strive towards promoting well-being through a healthy diet. The products target the discriminating health conscious consumer, who cares about using natural food ingredients for their nutrition requirements and those who believe that their health can be managed better through foods. This unit follows the philosophy of healthy and tasty foods while adding value by bringing to market product lines fortified with clinically validated nutritional bioactives developed by the FFM team. Products are currently sold in India and will enter Europe and US in 2009.

 

The BioAgriculture (or Seed-for-FoodTM) group focuses on biotic and abiotic stress resistance, oil enhancement and developing functional foods from plants. It hosts three wholly owned subsidiaries, large collaborative programs with the likes of Limagrain and Godrej and sees itself as a vehicle of high quality seed transmutation, wherein crops are developed through a combination of genetic and genomic tools, conventional and markers assisted breeding, exploiting natural and directed variation and trans/cisgenics. The aim is to combine/create germplasm with in-house technologies to enhance trait based solutions for farmers in India and across the globe. 

 

Personalised Healthcare

 

In the Science and Innovation group, technologies are being developed through collaborative R and D with global partners in the life sciences industry. It is the R and D heart of Avesthagen where new ideas are incubated and the main driver in the creation of high value IP. Over the years numerous collaborations have emerged from this program and evolved into new ventures. Others have also attracted equity investments in the parent company. The Science and Innovation business unit of Avesthagen employs a Systems Biology approach for the dissection of molecular mechanisms in human diseases and works towards delivery of innovative solutions for predictive, preventive, personalized healthcare. To take a product or a technology from concept to market is Science and Innovation’s greatest strength.

 

Science and Innovation currently covers four programs: AVESTAGENOMETM (a flagship large scale population genomics study on Parsis), Cancer Stem Cells, Molecular Diagnostics and, finally, Natural Drug Discovery.    

 

Under the BioPharmaceuticals group a solid pipeline of biosimilars is being developed in partnership with Cipla Limited The group focuses on pathway engineering and development of novel expression systems, development of product specific bioassays and design of novel animal component free production media, generation of over-expressing stable cell lines, development of proprietary expression platforms and novel, scalable processes in microbial and mammalian systems. Scale-up, manufacturing and supply of commercial scale material is done through a joint venture with certified manufacturing facilities in India and Malaysia. The first products are expected to reach the market early 2011 and will be sold in unregulated markets through Cipla’s distribution network. Regulated markets will be penetrated post patent expiry. 

 

First mover advantage, strategic positioning and worldwide collaborations saw the company progress towards its goal of bringing new safe medicine faster to the world whilst keeping social and ecological aspects in mind. Avesthagen recognise that corporate responsibility does not end at the factory gate or at office doors and that economic performance and attention to people go hand in hand. 

 

Avesthagen has built number of collaborations including joint ventures and equity led deals with global partners generating significant IP portfolio – valued by independent parties at Eur 2 Bn. In addition, they received numerous international certifications and awards. Revenues have progressed steadily since 2006 and they have seeing fast growth compared to the usual gestation period in the biotech industry. The company has raised to date more than Eur 40 million in equity that have been carefully deployed on four acquisitions and a substantial product portfolio and pipeline. Avesthagen is armed with international manufacturing, distribution and marketing capabilities.

 

HISTORY AND MILESTONE

 

1998

Avesthagen was founded by Dr. Villoo Morawala-Patell

2001

Avesthagen started its business operations

2001

Avesthagen received raised $1.5 million from ICICI Venture Funds as first round of venture funding

2001

Global Trust Bank became a strategic investor by investing Rs.20.000 millions

2001

TATA Industries Limited has picked up 5% stake in Avesthagen

2001

Avesthagen has announced an exclusive tie-up with the US-based Genetic Id Inc, thus becoming the first Indian Company to offer globally approved testing and certification for Genetically Modified Organisms (GMO’s).

2002

Avesthagen has tied up with pharma major AstraZeneca for drug discovery program in tuberculosis (TB).

2002

Avesthagen has been rated amongst the top five life sciences companies for its business plan presented at the TiEcon, 2002 (the world's largest conference on entrepreneurship held in Silicon Valley, US) held at Westin, Santa Clara, California.

2002

Wipro ties up with Avesthagen to explore BT

2003

The one billion euro French biotechnology giant, bioMerieux, in collaboration with Avesthagen, is setting up a global research project in Bangalore to develop diagnostic solutions for Tuberculosis (TB).

2003

Avesthagen has announced the launch of new facilities in Andhra Pradesh in International Crops Research Institute for the Semi-Arid Tropics (lCRISAT) at Patancheru

2003

Avesthagen entered into a alliance with bioMerieux to develop diagnostic kit based on the Affymetrix gene chip technology.

2003

Avesthagen has tied up with Imperial College London for population genomics study. The project is expected to focus on systemic lupus erythematosus (SLE) a generalized autoimmune disease

2003

Avesthagen has tied-up with state government of Andhra Pradesh and the international Crop Research Institute for Semi Arid Tropics (ICRISAT) to provide technological support to the emerging food, water and seed-testing sectors.

2003

Avesthagen and Kerala Government signed an MoU and agreed to set up a special purpose vehicle (SPV),

2003

Avesthagen gets US patents for multiple use technology

2004

Avesthagen ties up with CIPLA Limited

2004

Avesthagen received Rs. 27.500 Millions CSIR grant for DHA research

2004

Avesthagen has obtained exclusive market rights to Raisio’s top-selling product, Benecol, in India.

2004

Godrej Industries Limited picks up Stake in Avesthagen

2004

Ranbaxy Laboratories Limited and Avesthagen have signed a long term collaborative research agreement in the area of new drug discovery research

2004

Ahmedabad based Intas Pharmaceuticals Limited and Avesthagen have entered into a collaboration wherein Avesthagen will develop novel laboratory and pilot plant scale processes for expression of recombinant proteins for Intas.

2004

Avesthagen and Nordic Bio-sciences, a subsidiary of the Denmark-based Center for Clinical and Basic Research (CCBR), have announced a strategic joint venture Avesta Nordic Research Private Limited

2005

Avesthagen ties up with US Company Sequenom

2005

Expansion of Laboratory and Office space (14,500 sq ft) into Innovator building at ITPL

2005

Acquisition of Good Earth Foods Private Limited

2005

Inception of Avesta Biotherapeutics and Research Private Limited (JV with Cipla Limited, India)

2005

Strategic alliances with Nestle Nutrition SA, Novartis AG and with TNO Quality of Life

2005

Dr. Patell received the GR8! Women Award for Science and Technology

2005

Series B – follow-on investments by bioMérieux SA, France, and Godrej Industries Limited, India.

2005

Granting of “Pearl Millet” patent in Australia

2006

Signing of agreement for construction on new headquarters with Ascendas within ITPL campus, Bangalore.

2006

Winner of the Red Hearing Asia Award for “Disruptive Innovation”

2006

Expansion of Laboratory and Office space (4,000 sq ft) into Discoverer building at ITPL

2006

Grant from Indian Department of Biotechnology under the SBIRI scheme.

2006

R and D tie up with Group Danone

2006

Strategic Alliance with Groupe Limagrain, France and inception of Atash Seeds Private Limited

2006

Extension of Nestlé Nutrition Deal

2006

Dr. Villoo Morawala-Patell receives the BioSpectrum Entrepreneur of the Year Award 2006

2007

Avesthagen gets patent for salt tolerant rice

2007

Avesthagen IP model achieves global benchmark valuation of Euro 115 mn

2007

Avesthagen announces the closure of Series "C" round Euro 25 mn. New Investors are Fidelity, Daninvest, Limagrain and Bennett Coleman Company Limited

2007

AVESTHAGEN-ONE, Avesthagen breaks ground for its new corporate headquarters and RandD center at International Technology Park, Whitefield, Bangalore

2007

Avesthagen launches THE AVESTAGENOME PROJECTTM, Undertakes path breaking project for Novel Therapies and Diagnostics

2007

The Avestagenome Project Nature, March 29, 2007

2007

Dr. Villoo Morawala-Patell received the 2006 FICCI AWARD

2007

Avesthagen and Manipal Acunova announce collaboration in drug discovery, pre-clinical, clinical research including regulatory matters

2007

Avesthagen Receives INR 225 Million Share Capital Investment from NYLIM India Fund

2007

Avesthagen-Limagrain announces co-acquisition of majority stake in two seed companies

2007

Avesthagen enters into agreement with Malaysian Biotechnology Corporation to manufacture Bio Similar products

2007

Dr. Villoo Morawala-Patell’s profile was published in Nature Biotechnology, July 2007

2007

Avesthagen Acquires US Dietary Supplement Company Renaissance Herbs, Inc. (RHI)

2007

Avesthagen receives Australian Patent “A process for generating cytoplasmic male sterile line in rice and other crops by RNA editing”

2007

Avesthagen-CIPLA Joint Venture acquires Siegfried Biologics GmbH company

2007

Avesthagen arm acquires Siegfried Biologics

2007

Dr. Villoo Morawala-Patell takes over as Chairman of Avesthagen

2008

AVESTHAGEN becomes AVESTHAGEN LIMITED

2008

Avesthagen Limited launches Avestaä brand of plant–based bioactives

2008

Parsi communities in Hyderabad, Navsari and Surat provide participative support to The AVESTAGENOME Project™.

2008

Avesthagen begins Phase III Human clinical Studies for its AVESTA BRAND OF Bioactives.doc

2008

Affymetrix Signs Agreement With Avesthagen Limited

2008

AVESTHAGEN LIMITED and DuBiotech to enter into a Joint Venture

2008

AVESTHAGEN LIMITED and LIMAGRAIN Introduce India’s First 100% Biodegradable Plastic

2008

France Government honors and awards Dr. Villoo Morawala – Patell ‘Officer of the National Order of Merit’

2008

Avesthagen launches Whole wheat crackers with Teestar - a clinically validated bioactive that would help those who are prone to Type II diabetes

2008

AVESTHAGEN announces the clinical trial results of TeestarTM

2008

Avesthagen partners with ShigaMediX to develop vaccines for cervical cancer and tuberculosis

2008

ABRPL Gets RCGM’s Nod for Pre-Clinical Evaluation of Biopharmaceutical Products

2008

Avesthagen and ICMR join to promote biomedical research in India

2008

Dr. Villoo Morawala-Patell Receives the Prestigious ‘Astitva Award’ for Excellence in Science and Technology

2008

Avesthagen Limited and Mallika Sarabhai Present “And They Came to India

2008

Avesthagen Limited’s new Strategic Scientific Advisory Board addresses its multidisciplinary product pipeline

2008

Avesthagen Limited’s Intellectual Property For Diabetes Management Valued at $470 million

2008

Avesthagen Limited’s gets “License To Heal”: To Manufacture Bioactives for Ayurvedic Drugs

2008

Dr. Villoo Morawala-Patell Awarded For Achievement in Innovation And Creation Of Value. Award Conferred By The Adolfo Ibanez University

2009

AVESTHAGEN LIMITED Appoints Two Independent Board Members

2009

His Excellency Dr Boni Yayi, President, Republic of Benin today visited the campus of AVESTHAGEN LIMITED, at ITPB, Bangalore.

2009

Outstanding Entrepreneur of the Year; Dr. Villoo Morawala-Patell, Conferred Upon By The World Zarathusthi Chamber of Commerce (WZCC) at Houston,Texas, USA

2009

Avesthagen sails into Latin American waters. Forms Avesthagen Latam SpA to tap a large emerging market for its technologies, products and services. Announces strategic alliance with Chilean biotech company - Uxmal S.A.  The venture is being actively supported by the Chilean government.

2009

Avesthagen and The Harvard Medical School (HMS) Department of Genetics sign MOU to share knowledge and services in the field of Genomics

2009

Avesthagen and VTT Technical Research Centre of Finland, sign MOU to conduct product-based research projects in the  field of Theranostics

2009

AVESTHAGEN to initiate Clinical Trials for biosimilar AVDESP™

2009

Avesthagen revives IPO plans

2009

Avesthagen forms global Joint Venture with Limagrain in ATASH Seeds Private Limited 'Novel seeds for the challenges of the changing environment'

2009

Dr. Villoo Morawala Patell received prestigious ‘Karmaveer Puraskar’ as a ‘Corporate Citizen’ for her contribution in the field of agriculture and healthcare in Nov 2009 by iCONGO (Indian Confederation of NGOs) and Karmaveer Puraskar is a National Award for Social Justice and Citizen Action

2010

Avesthagen Limited was granted Patent registration for trapezoidal packaging design of its Good Earth Foods range of Products. The sub-category 09-03 includes Boxes, Cases, Containers, (Preserve) Tins and Cans and is effective from Jan 31, 2008.

2010

Avesthagen's Strategic Scientific Advisory Board meeting was held on Feb 15, 2010

2010

Avesthagen achieves significant commercial milestone
Sends first batch of cell lines for cGMP production of Clinical grade biosimilars to Inno Biologics, Malaysia

2010

Avesthagen moves towards Clinicals of its biosimilar AVENTTM

2010

Jacques Vincent joins Avesthagen Board.

 

 

MANAGEMENT

 

Dr. Villoo Morawala Patell

Founder, Chairperson and Managing Director

Dr. Villoo Morawala-Patell is an Academic Entrepreneur who founded Avesthagen in 1998. Avesthagen is globally recognized as a leading systems biology company with a unique model focused on the convergence of food, pharma and population genetics. A convergence that leads to continuous and path-breaking innovations in predictive, preventive, personalized healthcare. Owing to her pioneering work in the field of molecular biology, Dr. Patell has long-standing professional relationships with individuals, institutions and corporates working in the domain of biotechnology across the world. She is a key member of the Task Force and Vision Group for Biotechnology, instituted by the State Government of Karnataka and founding member of the Association of Biotechnology Led Enterprises (ABLE). Dr. Patell was Awarded the 'Officer of the National Order of Merit' by the President of the French Republic in April 2008.

 

Mr. Manoj Bawa

Chief Finance Officer

Mr Manoj Bawa joined the Company as Chief Finance Officer in November 2009. He is a Chartered Accountant with 26 years rich experience in Finance and Accounts, Taxation and US Gaap. Before joining the Company, he worked with reputed Companies such as McAfee, Cisco, Talisma, and VeriFone ."

 

Mr. Koen Wentink

Chief of Corporate Alliances and JVs

Mr. Koen Completed his Master of Science Degree in Agriculture (Crop Science) at Wageningen Agricultural University. The Netherlands with Majors in Plant Breeding, Crop Modeling and Business Administration, he has immense experience in productivity improvement and management control in Europe and Asia in diverse businesses. Here at Avesthagen he is a member of the management team and responsible for ensuring corporate and legal functions of the company.

 

Dr. Mittur N Jagadish

Senior Vice President

bioAgriculture

Dr. Jagadish brings with him over 21 years of experience. He is a Former Director of Monsanto Research Center, India.

Dr. Jagadish obtained BSc (Hons) and MSc in Botany from Bangalore University and PhD from Trinity College University of Dublin, Ireland, in Yeast Cell Cycle and Genetics. Following postdoctoral work at The Waksman Institute of Microbiology (Rutgers University, NJ, USA) and The Boyce Thompson Institute for Plant Research (Cornell University, NY, USA) working on Yeast Mating loci and Plant Microbe Interaction respectively, he moved to University of Belfield, Germany to continue working on Plant Microbe Interaction. He then relocated to Melbourne, Australia, to work with CSIRO in the divisions of Protein Chemistry / Bio Molecular Engineering for 11 plus years working on development of expression systems, sub-unit vaccines against infectious bursal disease virus, plant virus-decorated antigen presentation systems and protein trafficking. He then returned to Bangalore in 1996 to work in VMSRF, NCBS and Astra-Zeneca. In 1999, he joined Monsanto Research Center, an R and D unit of the Agriculture Biotechnology Company Monsanto, USA, to initiate and lead Genome Knowledge Enhancement Program. He then worked as the director of MRC for over 5 years before leaving to become a consultant in Biotechnology for 6 months.

 

Mr. Pierre Socha

Senior Vice President

Corporate Strategy and Planning

Pierre specialises in finance and strategy in the fields of life sciences and clean techs. He joined Avesthagen in 2002 and is heading the group corporate strategy since 2005. His role covers strategy development and implementation, corporate finance, competitive intelligence, global alliances, M and As and PMI. Over the years he held several management positions at Avesthagen: CEO, bioNutrition Division (2008-2010), Managing Director - Europe (2004-2008) and Head Business Development, Biomarkers and Diagnostics (2002-2004). Pierre serves on several boards and industry bodies. Prior to joining us, he worked as auditor and financial engineer for KPMG and Natixis (aka. Natexis Banques Populaires) respectively and as a research fellow at GREQAM-CNRS, France where he focused on game theory in clean techs and environmental economy.


Pierre holds a MSc (Hons) in Environmental Economics from Université de Provence (Aix-Marseille I), Faculty of Economy and Management (GREQAM, CNRS), France and a BSc. in Finance and Econometrics (Math Spe.) from Université Louis Pasteur (Strasbourg I), Faculty of Finance and Economy (BETA, CNRS), France. He attended the Strategy program (SBSCA) at Harvard Business School, MA-USA, Clean Energy program at Massachusetts Institute of Technology (MIT), MA-USA and the Marketing program of Stanford Graduate School of Business (GSB), CA-USA. Pierre is currently a Chartered Financial Analyst (CFA) candidate.

 

Dr. Anil Ram Chauhan

Senior Vice President

Operations

Dr. Anil Ram Chauhan is a gold medalist from HPU and earned his Ph.D. in Genetics from College of Basic Sciences (PAU) and a MBA in International Business from Baruch College , New York. In 1984, he topped the Indian Agri. Scientists Recruitment Board in Plant Breeding. He has worked as Vice President (Marketing) in Indo-American Hybrid Seeds and as Business Head in Deepak Agro Solutions Limited and Emergent Genetics India Private Limited.

 

Dr. Sami N Guzder

Chief Scientific Officer

Science and Innovation

Sami N. Guzder obtained his B.Sc. (Hons) in Chemistry and a M.Sc. in Biochemistry from University of Bombay. He was awarded a Ph.D. in Biochemistry from Louisiana State University for research on the isolation and characterization of DNA repair proteins from Drosophila melanogaster. Postdoctoral research work at the University of Rochester, New York, focused on dissecting the molecular basis of DNA repair processes in yeast and human. As a Research Scientist at the Center for Molecular Science, University of Texas Medical Branch-Galveston he continued his work in the area of DNA repair and transcription.

 

At Avesthagen Dr. Guzder is Chief Scientist for the Science and Innovation division. Dr. Guzder is involved in the design and supervision of diverse R and D projects resulting in the development of molecular diagnostics for various diseases. Dr. Guzder is currently leading The AVESTAGENOME ProjectTM, which is a population genomics and systems biology based study on the Parsi population to uncover the basis of longevity and discovery of novel biomarkers and drug targets for certain diseases.

 

Dr. Renuka Jain

Chief Scientific Officer

bioNutrition

Renuka Jain obtained her B.Sc. and a M.Sc. in Botany from Jiwaji University, Gwalior. She was awarded a Ph.D. in Botany from Jiwaji University, Gwalior for research on the regulation of petal senescence. Dr. Jain then spent 3 years at the Umea Plant Science centre, Sweden and another year at University of Missouri-Columbia, USA for her post-doctoral research.

 

For the last two years, Dr. Jain has been heading the bioNutrition division and is involved in the supervision of various research and discovery projects for the development of novel plant bioactives for diabetes, cardiovascular health, calorie management, bone health.

 

Mr. Manan Bhatt

Senior Vice President

External Relations

Manan Bhatt has 27 years' rich experience in business development of Indo-European technology and investments having worked with MNCs such as IRI and ENI groups of Italy and BNP-Paribas of France. He also had 4yrs tenure with UNIDO (United Nations Industrial Development Organization) as the Representative of India in France, for the promotion of Indo-French technology investments and business partnerships.

 

He has a management degree in international economic relations from the prestigious 'Center for Higher Studies on Africa and Modern Asia' (CHEAM) in Paris, (1995-96). Since July 2003, Mr. Bhatt is working as senior vice president (external relations) with Avesthagen.

 

SUBSIDIARIES

 

Avesta Good Earth Foods Private Limited (AGEF)


Avesta Good Earth Foods is an Indian food company with global ambitions, dedicated to developing nutritious alternatives for breakfast, daily snacks, and functional food for all who strive towards promoting wellbeing through a healthy diet. They add value by developing and marketing product lines Fortified with nutritional bioactives Sourced from traditional Indian medicine Clinically validated by techniques of modern science. Avesta Good Earth Foods will play a key role in Avesthagen's long-term strategy to launch its branded nutraceuticals as Functional Foods targeting the burgeoning health foods market in India. The new line of business will also complement the company's core philosophy of promoting good health and wellbeing in India and abroad.

 

Avesthagen Inc


At Avesthagen, we’re devoted to the research and manufacture of quality high-potency, clinically validated, botanical bioactive ingredients, derived from traditional medicinal plants Their signature ingredients have scientifically validated health benefits to promote wellness through the prevention of specific degenerative and address conditions such as – diabetes, obesity, metabolic syndrome, CVD and bone loss. They combine nature, tradition and technology to create innovative ingredients that meet consumer needs for great taste, better nutrition and heath and wellness, as well as a commitment to environmental sustainability.

 

Avesthagen Quality Agriculture Services Private Limited (AQUAS)


AQUAS is a subsidiary of Avesthagen that has been established for the purpose of food, water and seed purity testing as well as seed development in their labs located in Hyderabad.

 

 

JOINT VENTURES

 

ATASH Seeds Private Limited


Avesthagen established 'ATASH SEEDS PRIVATE LIMITED as a vehicle to deliver the latest Agbiotechnology technologies developed within Avesthagen dealing with agricultural productivity and production. The forefront technologies developed by Avesthagen and desperately required in India and the developing world are: HybridFITTM, DroughtFITTM and SalinityFITTM; whereas all countries would benefit from their NutritionFITTM technology.

 

Avesta Biotherapeutics and Research Private Limited (ABRPL)

 

Avesthagen and Meditab Specialities Limited have embarked on a manufacturing Joint Venture for production of Biopharmaceuticals in India. The JV, Avesta Biotherapeutics and Research Private Limited based in Bangalore, will manufacture a new generation of targeted therapies that are already in development through the ongoing development programme that was announced last year. In addition, the venture will exploit opportunities in Biologicals Contract Manufacturing worldwide - a fast expanding growth segment in the pharmaceuticals arena.

 

AVA Seeds Private Limited


Avesthagen has also established ‘AVA SEEDS PRIVATE LIMITED’ as a vehicle to deliver the latest Agbiotechnology technologies developed within Avesthagen dealing with Vegetable productivity and production. The forefront technologies developed by Avesthagen and desperately required in India and the developing world are: High Lycopene Tomatoes, and Marker Assisted Breeding for quantity and quality enhancement in Vegetable crops; whereas the developed world would benefit greatly from NutritionFITTM technology for oilseed crops.

 

PRESS RELEASE

 

Avesthagen - Kemwell Manufacturing Alliance for Biosimilars

 

Bangalore, May 10, 2011: Avesthagen Limited and Kemwell Biopharma Private Limited signed a Memorandum of Understanding (MoU) that will enable Avesthagen to leverage Kemwell’s biopharmaceutical manufacturing expertise for large scale manufacture of biosimilars. Avesthagen has a portfolio of eight biosimilars under various phases of development in the areas of autoimmune diseases, cancers, anemia, and cardiovascular disorders.

 

Kemwell will perform technology transfer, process improvement, scale - up and manufacturing of pre-clinical, clinical and commercial material of Avesthagen biosimilars.

 

Kemwell’s new 15,000 sq. mt. Greenfield state-of-the-art facility in Bangalore includes process development labs, a cGMP facility with cell culture capacity of 2 x 2000 liters for drug substance manufacturing, and a cGMP drug product manufacturing facility with vial filling, lyophilization and prefilled syringes capabilities that would be used for Avesthagen.

 

Biosimilars are one of the most keenly watched group of pharmaceuticals that are seen as a panacea for the lack of reasonably priced medicines in the developing and developed economies. Many blockbuster and high-priced biologics are to go offpatent in the next decade and biosimilar manufacturers are expected to reap the benefits.

 

Dr. Villoo Morawala-Patell, founder and Chairperson, Avesthagen stated, “Kemwell is well placed to accelerate Avesthagen’s projects to get its Biosimilars to the global markets. Given Kemwell’s global capabilities in terms of capacities, experience and expertise, Avesthagen has found a partner that is globally recognized to consistently deliver superior quality product in a timely manner. This enables Avesthagen to bring its products a step closer to the market.”

 

Mr. Anurag Bagaria, CMD, Kemwell stated, “Over the last 30 years, Kemwell has always placed emphasis on delivering quality products on time and on a consistent basis. We are excited to begin work for Avesthagen from our new biologics facility and are confident of extending our record of high customer service to this new foray.”

 

About Avesthagen Limited:

Avesthagen is India’s leading integrated systems biology platform company that focuses on achieving convergence of food, pharma and population genetics leading to predictive preventive and personalized healthcare.

 

Avesthagen partners include multiple top 10 global companies in each of its fields of research. Since its inception Avesthagen has grown into one of India’s leading healthcare biotech companies. In addition to its agri-biotechnologies product pipeline it has developed clinically validated botanical bioActives and a strong pipeline of bio-similars.

 

About Kemwell Biopharma Private Limited

 

Bangalore-based Kemwell Biopharma Private Limited. is a leading provider of formulations contract manufacturing and development services for multinational pharmaceutical companies for 30 years. From facilities in India and Sweden, Kemwell manufactures tablets, capsules, liquid orals, external drops, ointments, gels and creams. Kemwell’s customers include 5 of the top 10 pharmaceutical companies in the world, manufacturing 4 of the top 10 brands in India. Kemwell’s Pharmaceutical Development Unit provides services in clinical manufacturing and packaging, formulation and analytical development, stability studies, regulatory documentation etc. With a 100% commitment to pure play contract manufacturing, Kemwell has no branded products of its own in the market, thereby avoiding any conflict of interests with its customers. Kemwell has recently built a new state-of-the-art biologics manufacturing facility in Bangalore to offer process development and GMP manufacturing services for drug substance and drug product.


 

CMT REPORT (Corruption, Money Laundering & Terrorism]

 

The Public Notice information has been collected from various sources including but not limited to: The Courts, India Prisons Service, Interpol, etc.

 

1]         INFORMATION ON DESIGNATED PARTY

No records exist designating subject or any of its beneficial owners, controlling shareholders or senior officers as terrorist or terrorist organization or whom notice had been received that all financial transactions involving their assets have been blocked or convicted, found guilty or against whom a judgement or order had been entered in a proceedings for violating money-laundering, anti-corruption or bribery or international economic or anti-terrorism sanction laws or whose assets were seized, blocked, frozen or ordered forfeited for violation of money laundering or international anti-terrorism laws.

 

2]         Court Declaration :

No records exist to suggest that subject is or was the subject of any formal or informal allegations, prosecutions or other official proceeding for making any prohibited payments or other improper payments to government officials for engaging in prohibited transactions or with designated parties.

 

3]         Asset Declaration :

No records exist to suggest that the property or assets of the subject are derived from criminal conduct or a prohibited transaction.

 

4]         Record on Financial Crime :

            Charges or conviction registered against subject:                                                              None

 

5]         Records on Violation of Anti-Corruption Laws :

            Charges or investigation registered against subject:                                                          None

 

6]         Records on Int’l Anti-Money Laundering Laws/Standards :

            Charges or investigation registered against subject:                                                          None

 

7]         Criminal Records

No available information exist that suggest that subject or any of its principals have been formally charged or convicted by a competent governmental authority for any financial crime or under any formal investigation by a competent government authority for any violation of anti-corruption laws or international anti-money laundering laws or standard.

 

8]         Affiliation with Government :

No record exists to suggest that any director or indirect owners, controlling shareholders, director, officer or employee of the company is a government official or a family member or close business associate of a Government official.

 

9]         Compensation Package :

Our market survey revealed that the amount of compensation sought by the subject is fair and reasonable and comparable to compensation paid to others for similar services.

 

10]        Press Report :

            No press reports / filings exists on the subject.

 


 

CORPORATE GOVERNANCE

 

MIRA INFORM as part of its Due Diligence do provide comments on Corporate Governance to identify management and governance. These factors often have been predictive and in some cases have created vulnerabilities to credit deterioration.

 

Our Governance Assessment focuses principally on the interactions between a company’s management, its Board of Directors, Shareholders and other financial stakeholders.

 

 

CONTRAVENTION

 

Subject is not known to have contravened any existing local laws, regulations or policies that prohibit, restrict or otherwise affect the terms and conditions that could be included in the agreement with the subject.

 

 

FOREIGN EXCHANGE RATES

 

Currency

Unit

Indian Rupees

US Dollar

1

Rs.45.29

UK Pound

1

Rs.73.84

Euro

1

Rs.64.18

 


 

SCORE & RATING EXPLANATIONS

 

SCORE FACTORS

 

RANGE

POINTS

HISTORY

1~10

5

PAID-UP CAPITAL

1~10

4

OPERATING SCALE

1~10

5

FINANCIAL CONDITION

 

 

--BUSINESS SCALE

1~10

4

--PROFITABILIRY

1~10

2

--LIQUIDITY

1~10

4

--LEVERAGE

1~10

3

--RESERVES

1~10

3

--CREDIT LINES

1~10

3

--MARGINS

-5~5

-

DEMERIT POINTS

 

 

--BANK CHARGES

YES/NO

YES

--LITIGATION

YES/NO

NO

--OTHER ADVERSE INFORMATION

YES/NO

NO

MERIT POINTS

 

 

--SOLE DISTRIBUTORSHIP

YES/NO

NO

--EXPORT ACTIVITIES

YES/NO

NO

--AFFILIATION

YES/NO

YES

--LISTED

YES/NO

NO

--OTHER MERIT FACTORS

YES/NO

YES

TOTAL

 

33

 

This score serves as a reference to assess SC’s credit risk and to set the amount of credit to be extended. It is calculated from a composite of weighted scores obtained from each of the major sections of this report. The assessed factors and their relative weights (as indicated through %) are as follows:

 

Financial condition (40%)            Ownership background (20%)                 Payment record (10%)

Credit history (10%)                    Market trend (10%)                                Operational size (10%)

 


 

RATING EXPLANATIONS

 

 

RATING

STATUS

 

 

PROPOSED CREDIT LINE

>86

Aaa

Possesses an extremely sound financial base with the strongest capability for timely payment of interest and principal sums

 

Unlimited

71-85

Aa

Possesses adequate working capital. No caution needed for credit transaction. It has above average (strong) capability for payment of interest and principal sums

 

Large

56-70

A

Financial & operational base are regarded healthy. General unfavourable factors will not cause fatal effect. Satisfactory capability for payment of interest and principal sums

 

Fairly Large

41-55

Ba

Overall operation is considered normal. Capable to meet normal commitments.

 

Satisfactory

26-40

B

Capability to overcome financial difficulties seems comparatively below average.

 

Small

11-25

Ca

Adverse factors are apparent. Repayment of interest and principal sums in default or expected to be in default upon maturity

 

Limited with full security

<10

C

Absolute credit risk exists. Caution needed to be exercised

 

 

Credit not recommended

-

NB

                                       New Business

-

 

 

 

 

PRIVATE & CONFIDENTIAL : This information is provided to you at your request, you having employed MIPL for such purpose. You will use the information as aid only in determining the propriety of giving credit and generally as an aid to your business and for no other purpose. You will hold the information in strict confidence, and shall not reveal it or make it known to the subject persons, firms or corporations or to any other. MIPL does not warrant the correctness of the information as you hold it free of any liability whatsoever. You will be liable to and indemnify MIPL for any loss, damage or expense, occasioned by your breach or non observance of any one, or more of these conditions

This report is issued at your request without any risk and responsibility on the part of MIRA INFORM PRIVATE LIMITED (MIPL) or its officials.